![]() ![]() It was found that EGCG (100 mg/kg, i.p.) treatment significantly reduced brain water content and vascular permeability at 12, 24, 48, 72 hour after TBI. At different times following trauma, rats were sacrificed for analysis. Rats were administered with 100 mg/kg EGCG or PBS intraperitoneally. ![]() In this study, a weight drop model was established to evaluate the therapeutic potential of EGCG on TBI. In spite of numerous studies suggesting that Epigallocatechin-3-gallate ( EGCG) has been used as a therapeutic agent for a broad range of disorders, the effect of EGCG on TBI remains unknown. Traumatic brain injury (TBI) is a major cause of mortality and long-term disability, which can decrease quality of life. Zhang, Bo Wang, Bing Cao, Shuhua Wang, Yongqiang Epigallocatechin-3-Gallate ( EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress. ![]()
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